Unveiling the phototheranostic potential of a hydrazine-bridged polymeric fluorophore with an amino-single-benzene core
- Authors
- KIM, SUNG CHEOL
- Issue Date
- 2026-07
- Publisher
- Elsevier Ltd
- Citation
- 논문 Dyes and Pigments, v.250, no.2026, pp.113664-113664
- Journal Title
- Dyes and Pigments
- Volume
- 250
- Number
- 2026
- Start Page
- 113664
- End Page
- 113664
- ISSN
- 0143-7208
- Abstract
- Photodynamic therapy (PDT) is a promising adjuvant strategy in oncology owing to its spatial selectivity and minimal invasiveness. However, conventional small-molecule photosensitizers (PSs) often exhibit poor biostability, limited tumor targeting, and phototoxicity. While polymeric PSs have been developed to mitigate these issues, design strategies have largely been restricted to π-conjugated systems to ensure efficient intersystem crossing (ISC). In this study, we overcame the limitations of single-benzene-based fluorophores (SBBFs), which typically exhibit strong fluorescence but negligible reactive oxygen species (ROS) generation, using a polymerization strategy. We present HPD, a hydrazine-bridged non-π-conjugated polymeric SBBF that exhibits pronounced fluorescence quenching and robust ROS production (singlet oxygen and superoxide radicals) upon laser irradiation, in line with increased access to triplet states. HPD exhibited selective accumulation in HeLa and B16F10 tumor cells, inducing significant PDT-mediated cytotoxicity. As the first report of an SBBF-based hydrazine-bridged polymer with PDT efficacy, HPD offers a novel platform for the development of next-generation phototheranostic agents. © 2026 Elsevier Ltd
